KDM4A Antikörper

Produktnummer ABIN6943852

Der Kaninchen Polyklonal Anti-KDM4A-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, KDM4A in Proben von Human zu detektieren.

Kurzübersicht für KDM4A Antikörper (ABIN6943852)

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-KDM4A Antikörper

Kreuzreaktivität: Human

Aufreinigung: Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.

Immunogen: Polyclonal antibody raised in rabbit against human JMJD2a (Jumonji domain containing 2a), using a KLH-conjugated synthetic peptide containing a sequence from the central part of the protein

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IF()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 μg/μL

Buffer: PBS with 0.05 % sodium azide and 0.05 % Proclin300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu KDM4A

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Andere Bezeichnung: JMJD2a

Hintergrund:

Synonyms: JHDM3A, KDM4A, JMJD2, Lysine-specific demethylase 4A

Background: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Gen-ID: 9682

UniProt: O75164

Pathways: Warburg Effekt