Huntingtin Antikörper
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- Target Alle Huntingtin (HTT) Antikörper anzeigen
- Huntingtin (HTT)
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser Huntingtin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- Recombinant protein within human Huntingtin aa 1-150
- Klon
- 1F10
- Isotyp
- IgG
- Top Product
- Discover our top product HTT Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Huntingtin (HTT)
- Andere Bezeichnung
- Huntingtin (HTT Produkte)
- Synonyme
- HTT antikoerper, hd antikoerper, ZHD antikoerper, CG9995 antikoerper, Dmel\\CG9995 antikoerper, HD antikoerper, Hsap\\HD antikoerper, Htt antikoerper, dHtt antikoerper, dhtt antikoerper, SLC6A4 antikoerper, huntington antikoerper, it15 antikoerper, htt antikoerper, IT15 antikoerper, AI256365 antikoerper, C430023I11Rik antikoerper, Hd antikoerper, Hdh antikoerper, huntingtin antikoerper, HTT antikoerper, htt antikoerper, LOC373520 antikoerper, Htt antikoerper
- Hintergrund
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Synonyms: Huntingtin, Huntington disease protein, HD protein, HTT, IT15, LOMARS
Background: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. Huntingtin may play a role in microtubule-mediated transport or vesicle function.
- Gen-ID
- 3064
- UniProt
- P42858
- Pathways
- PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
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