HDAC2 Antikörper

Produktnummer ABIN6943609

Der Maus Monoklonal Anti-HDAC2-Antikörper wurde für WB, ELISA, IF (cc), ChIP-seq und DB validiert. Er ist geeignet, HDAC2 in Proben von Human zu detektieren.

Kurzübersicht für HDAC2 Antikörper (ABIN6943609)

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HDAC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), ChIP DNA-Sequencing (ChIP-seq), Dot Blot (DB)

Klon: 7G5

Produktdetails anti-HDAC2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Protein A purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300

Immunogen: Monoclonal antibody raised in mouse against human HDAC2 (Histone deacetylase 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IF(ICC) 1:50-200
dot-blot()
ChIP-seq()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Andere Bezeichnung: HDAC2

Hintergrund:

Synonyms: HD2, RPD3, YAF1

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Gen-ID: 3066

UniProt: Q92769

Pathways: Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion