HDAC2 Antikörper

Produktnummer ABIN5557480

Produktdetails anti-HDAC2 Antikörper

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HDAC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant human HDAC2 protein, around C-terminal 150aa.

Klon: 3B7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Andere Bezeichnung: HDAC2 (HDAC2 Produkte)

Synonyme: HD2 antikoerper, RPD3 antikoerper, YAF1 antikoerper, D10Wsu179e antikoerper, Yy1bp antikoerper, mRPD3 antikoerper, HISTONE DEACETYLASE antikoerper, T1N24.9 antikoerper, T1N24_9 antikoerper, histone deacetylase 2 antikoerper, histone deacetylase 2 antikoerper, histone deacetylase 2 S homeolog antikoerper, HDAC2 antikoerper, Hdac2 antikoerper, hdac2.S antikoerper, HDA2 antikoerper

Hintergrund:

Synonyms: HD2, RPD3, YAF1, Histone deacetylase 2, HDAC2

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Gen-ID: 3066

UniProt: Q92769

Pathways: Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion