GRK2 Antikörper
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- Target Alle GRK2 (ADRBK1) Antikörper anzeigen
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser GRK2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- Recombinant Human GRK2 between 470 to 700 amino acids
- Klon
- 42D1
- Isotyp
- IgG
- Top Product
- Discover our top product ADRBK1 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- Andere Bezeichnung
- GRK2 (ADRBK1 Produkte)
- Synonyme
- Adrbk-1 antikoerper, Bark-1 antikoerper, GRK2 antikoerper, betaARK1 antikoerper, BARK1 antikoerper, BETA-ARK1 antikoerper, GRK-2 antikoerper, Grk2 antikoerper, beta-adrenergic receptor kinase 1 antikoerper, G protein-coupled receptor kinase 2 antikoerper, Tsp_00497 antikoerper, grk2 antikoerper, Grk2 antikoerper, GRK2 antikoerper
- Hintergrund
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Synonyms: Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, Beta-ARK-1, ADRBK1, BARK, BARK1, GRK2
Background: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
- Gen-ID
- 156
- UniProt
- P25098
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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