CD51 Antikörper

Produktnummer ABIN6941316

Produktdetails anti-CD51 Antikörper

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reaktivität: Human, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD51 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Spezifität: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

Keine Kreuzreaktivität: Rind (Kuh), Schwein, Kaninchen

Aufreinigung: Purified by Protein A/G

Immunogen: Osteoclasts from osteoclastomas

Klon: 23C6

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Squamous cells, A375M melanoma cells. A549 cells.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Andere Bezeichnung: ITGAV (ITGAV Produkte)

Synonyme: 1110004F14Rik antikoerper, 2610028E01Rik antikoerper, CD51 antikoerper, D430040G12Rik antikoerper, MSK8 antikoerper, VNRA antikoerper, VTNR antikoerper, Cd51 antikoerper, integrin subunit alpha V antikoerper, integrin alpha V antikoerper, ITGAV antikoerper, Itgav antikoerper

Molekulargewicht: 150-160kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130kDa +20-25kDa.

Gen-ID: 3685

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex