TAL1 Antikörper

Produktnummer ABIN6940680

Der Maus Monoklonal anti-TAL1 Antikörper wird verwendet zum Nachweis von TAL1 in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für TAL1 Antikörper (ABIN6940680)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TAL1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: TAL1-2707

Produktdetails anti-TAL1 Antikörper

Verwendungszweck: Tal1 Antibody

Spezifität: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human full-length TAL1 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: A549 xenograft.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Andere Bezeichnung: TAL1

Hintergrund:

bHLHa17, Class A basic helix-loop-helix protein 17, OTTHUMP00000009563, OTTHUMP00000009564, SCL, STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR, Stem cell protein, T cell acute lymphocytic leukemia 1, T cell acute lymphocytic leukemia 1 protein, T cell acute lymphocytic leukemia 1 protein, T cell leukemia/lymphoma 5 protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, Tal 1 product, TAL 1 protein, TAL bHLH transcription factor 1 erythroid differentiation factor, TAL-1

A549 xenograft.

Molekulargewicht: 42kDa

Gen-ID: 6886, 705618

UniProt: P17542

Pathways: Stem Cell Maintenance