SPTAN1 Antikörper (AA 2351-2475)

Produktnummer ABIN6940647

Dieses Anti-SPTAN1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SPTAN1 in IHC und StM. Geeignet für Human.

Kurzübersicht für SPTAN1 Antikörper (AA 2351-2475) (ABIN6940647)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Staining Methods (StM)

Klon: SPTAN1-3351

Produktdetails anti-SPTAN1 Antikörper

Bindungsspezifität: AA 2351-2475

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human SPTAN1 protein (around aa 2351-2475) (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human colon or kidney tissues (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: SPTAN1

Hintergrund: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.

Molekulargewicht: 240kDa

Gen-ID: 6709

UniProt: Q13813

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization