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beta-2 Microglobulin Antikörper

This anti-beta-2 Microglobulin antibody (ABIN6940412) is a Mouse Monoclonal antibody detecting beta-2 Microglobulin in FACS, IHC, IF, StM. Suitable for Human, Non-Human Primate.
Produktnummer ABIN6940412

Kurzübersicht für beta-2 Microglobulin Antikörper (ABIN6940412)

Target

Alle beta-2 Microglobulin (B2M) Antikörper anzeigen
beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reaktivität

  • 244
  • 69
  • 38
  • 26
  • 9
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Non-Human Primate

Wirt

  • 160
  • 138
  • 9
  • 6
  • 2
  • 1
Maus

Klonalität

  • 165
  • 150
  • 1
Monoklonal

Konjugat

  • 165
  • 35
  • 29
  • 14
  • 14
  • 8
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser beta-2 Microglobulin Antikörper ist unkonjugiert

Applikation

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  • 107
  • 81
  • 71
  • 70
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  • 39
  • 26
  • 18
  • 17
  • 14
  • 13
  • 10
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)

Klon

SPM617
  • Aufreinigung

    Purified by Protein A/G

    Immunogen

    Full length recombinant human B2M protein

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Positive Control: HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Cervix, Endometrial, Kidney or Colon.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-80 °C

    Informationen zur Lagerung

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Haltbarkeit

    24 months
  • Target

    beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

    Andere Bezeichnung

    B2M

    Hintergrund

    Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

    Molekulargewicht

    12kDa

    Gen-ID

    567

    UniProt

    P61769

    Pathways

    T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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