NKX3-1 Antikörper (AA 92-224)

Produktnummer ABIN6940208

Der Maus Monoklonal Anti-NKX3-1-Antikörper wurde für IHC, ELISA, Coat und StM validiert. Er ist geeignet, NKX3-1 in Proben von Human zu detektieren.

Kurzübersicht für NKX3-1 Antikörper (AA 92-224) (ABIN6940208)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NKX3-1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Coating (Coat), Staining Methods (StM)

Klon: NKX3-1-3350

Produktdetails anti-NKX3-1 Antikörper

Bindungsspezifität: AA 92-224

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Highly expressed in the prostate and at a lower level in the testis.

Known Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Andere Bezeichnung: NKX3-1

Hintergrund: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

Molekulargewicht: 35kDa

Gen-ID: 4824

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus