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FAS Antikörper (AA 26-96)

FAS Reaktivität: Human FACS, IHC, ELISA, IF, Coat, StM Wirt: Maus Monoclonal FAS-3112 unconjugated
Produktnummer ABIN6939781
  • Target Alle FAS Antikörper anzeigen
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Bindungsspezifität
    • 23
    • 15
    • 15
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 26-96
    Reaktivität
    • 216
    • 66
    • 64
    • 18
    • 9
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 165
    • 102
    • 3
    • 3
    • 1
    • 1
    • 1
    Maus
    Klonalität
    • 160
    • 115
    • 1
    Monoklonal
    Konjugat
    • 133
    • 27
    • 25
    • 12
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FAS Antikörper ist unkonjugiert
    Applikation
    • 172
    • 123
    • 76
    • 69
    • 61
    • 39
    • 33
    • 32
    • 24
    • 24
    • 17
    • 15
    • 8
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Coating (Coat), Staining Methods (StM)
    Spezifität
    This MAb specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45 kDa, containing 8 kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant fragment (around aa26-96) of human CD95 (FAS) protein (exact sequence is proprietary)
    Klon
    FAS-3112
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product FAS Primärantikörper
  • Applikationshinweise

    Positive Control: MCF-7 cells (IF/FACS). Human hepatocellular or bladder carcinoma (IHC).

    Known Application: ELISA (For coating, order Ab without BSA), Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    FAS (TNF Receptor Superfamily, Member 6 (FAS))
    Andere Bezeichnung
    FAS (FAS Produkte)
    Molekulargewicht
    38-50kDa
    Gen-ID
    355
    UniProt
    P25445
    Pathways
    p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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