HLA-B Antikörper
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- Target Alle HLA-B Antikörper anzeigen
- HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser HLA-B Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Aufreinigung
- Purified by Protein A/G
- Immunogen
- Normal human peripheral blood lymphocytes
- Klon
- JOAN-1
- Isotyp
- IgG3 kappa
- Top Product
- Discover our top product HLA-B Primärantikörper
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- Applikationshinweise
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Positive Control: Human peripheral blood lymphocytes, tonsil or lymph node.
Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Haltbarkeit
- 24 months
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- Target
- HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
- Andere Bezeichnung
- HLA-B (HLA-B Produkte)
- Synonyme
- AS antikoerper, HLAB antikoerper, SPDA1 antikoerper, mhc1b antikoerper, major histocompatibility complex, class I, B antikoerper, major histocompatibility complex nonclassical class Ib L homeolog antikoerper, HLA-B antikoerper, BOLA-B antikoerper, MAMU-B18 antikoerper, DKFZP469N1225 antikoerper, mhc1b.L antikoerper
- Hintergrund
- HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
- Molekulargewicht
- 45kDa
- Gen-ID
- 3106
- UniProt
- P01889
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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