TOX3 Antikörper (AA 251-389)

Produktnummer ABIN6939531

Der Maus Monoklonal Anti-TOX3-Antikörper wurde für WB, ELISA und Coat validiert. Er ist geeignet, TOX3 in Proben von Human zu detektieren.

Kurzübersicht für TOX3 Antikörper (AA 251-389) (ABIN6939531)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TOX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Coating (Coat)

Klon: TOX3-1124

Produktdetails anti-TOX3 Antikörper

Bindungsspezifität: AA 251-389

Spezifität: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Andere Bezeichnung: TOX3

Molekulargewicht: 63kDa

Gen-ID: 27324

UniProt: O15405

Pathways: Chromatin Binding