Cathepsin D Antikörper (AA 104-250)

Produktnummer ABIN6939218

Der Maus Monoklonal Anti-Cathepsin D-Antikörper wurde für IHC, IF und StM validiert. Er ist geeignet, Cathepsin D in Proben von Human zu detektieren.

Kurzübersicht für Cathepsin D Antikörper (AA 104-250) (ABIN6939218)

Target: Cathepsin D (CTSD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin D Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)

Klon: CTSD-3276

Produktdetails anti-Cathepsin D Antikörper

Bindungsspezifität: AA 104-250

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: MCF-7, K-562, A431 or SK-BR3 cells. Kidney, liver, lung or breast.

Known Application: Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Cathepsin D

Target: Cathepsin D (CTSD)

Andere Bezeichnung: CTSD

Hintergrund: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Molekulargewicht: 46kDa (Procathepsin D), 28kDa (Cathepsin D)

Gen-ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism