Peroxiredoxin 4 Antikörper

Produktnummer ABIN6939084

Dieses Anti-Peroxiredoxin 4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Peroxiredoxin 4 in ELISA und Coat. Geeignet für Human.

Kurzübersicht für Peroxiredoxin 4 Antikörper (ABIN6939084)

Target: Peroxiredoxin 4 (PRDX4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Peroxiredoxin 4 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Klon: CPTC-PRDX4-2

Produktdetails anti-Peroxiredoxin 4 Antikörper

Spezifität: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

Kreuzreaktivität (Details): Human,

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human PRDX4 protein

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

Positive Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Haltbarkeit: 24 months

Details zu Peroxiredoxin 4

Target: Peroxiredoxin 4 (PRDX4)

Andere Bezeichnung: PRDX4

Hintergrund: Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK,Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)
Cellular localisation: Cytoplasm. Secreted.

Molekulargewicht: 27kDa

Gen-ID: 10549, 83383

UniProt: Q13162