Rekombinanter TNFSF15 Antikörper
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- Target Alle TNFSF15 Antikörper anzeigen
- TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))
- Antikörpertyp
- Recombinant Antibody
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TNFSF15 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human full-length VEGI protein
- Klon
- RVEGI-1283
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product TNFSF15 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen or prostate.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))
- Andere Bezeichnung
- TNFSF15 (TNFSF15 Produkte)
- Synonyme
- TTPAL antikoerper, TL1 antikoerper, TL1A antikoerper, VEGI antikoerper, VEGI192A antikoerper, Tl1 antikoerper, Tl1a antikoerper, Vegi antikoerper, tumor necrosis factor superfamily member 15 antikoerper, TNF superfamily member 15 antikoerper, tumor necrosis factor (ligand) superfamily, member 15 antikoerper, TNFSF15 antikoerper, Tnfsf15 antikoerper
- Hintergrund
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TNF ligand-related molecule 1 (TL1A), Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15), Vascular endothelial growth inhibitor 192a, Vascular endothelial growth inhibitor (VEGI), VEGI192A,TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor)
Cellular localisation: Secreted and Cell Surface - Molekulargewicht
- 22kDa
- Gen-ID
- 9966, 241382
- UniProt
- O95150
- Pathways
- Positive Regulation of Endopeptidase Activity, Autophagie
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