SUMO2 Antikörper

Produktnummer ABIN6938469

Produktdetails anti-SUMO2 Antikörper

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SUMO2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, 2 and 3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include MDM2, p53, PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1 and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.

Kreuzreaktivität (Details): Human. Rat. Predicted to show a broad species reactivity.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human SUMO2 protein

Klon: SUMO2-1199

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HeLa cells. Breast carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu SUMO2

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Andere Bezeichnung: SUMO2 (SUMO2 Produkte)

Synonyme: HSMT3 antikoerper, SMT3B antikoerper, SMT3H2 antikoerper, SUMO3 antikoerper, Smt3A antikoerper, SMT3A antikoerper, SMT3H1 antikoerper, SUMO-3 antikoerper, Smt3B antikoerper, Smt3h2 antikoerper, sumo2 antikoerper, zgc:92241 antikoerper, SUMO2 antikoerper, SUMO-2 antikoerper, Smt3b antikoerper, hsmt3 antikoerper, smt3b antikoerper, smt3h2 antikoerper, sumo-2 antikoerper, PSMT3 antikoerper, ATSUMO2 antikoerper, MCO15.11 antikoerper, MCO15_11 antikoerper, SMALL UBIQUITIN-LIKE MODIFIER 2 antikoerper, SUM2 antikoerper, SUMO 2 antikoerper, small ubiquitin-like modifier 2 antikoerper, small ubiquitin-like modifier 2 antikoerper, small ubiquitin-like modifier 3 antikoerper, small ubiquitin-like modifier 2b antikoerper, small ubiquitin-related modifier 2 antikoerper, small ubiquitin-like modifier 2 S homeolog antikoerper, small ubiquitin-like modifier 2 L homeolog antikoerper, SUMO2 antikoerper, SUMO3 antikoerper, Sumo2 antikoerper, sumo2b antikoerper, LOC714892 antikoerper, sumo2.S antikoerper, sumo2.L antikoerper

Hintergrund: HSMT3, Sentrin 2, Small ubiquitin like modifier 2, Small ubiquitin like modifier protein 3, SMT3A, SMT3B, SMT3 homolog 1 (SMT3H1), SMT3 homolog 2 (SMT3H2), SMT3 homolog, SMT3 suppressor of mif two 3 homolog 1, SMT3 suppressor of mif two 3 homolog 2, SMT3 suppressor of mif two 3 homolog 3, Suppressor of mif two 3 homolog 2, Suppressor of mif two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B,SUMO-2
Cellular localisation: Nuclear

Molekulargewicht: 11-13kDa

Gen-ID: 6613, 474005

UniProt: P55854

Pathways: Methionine Biosynthetic Process