SREBF2 Antikörper

Produktnummer ABIN6938453

Produktdetails anti-SREBF2 Antikörper

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SREBF2 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Spezifität: The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human SREBF2 protein

Klon: SREBP2-1579

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: Ubiqutious expression in adult and fetal tissues. Hep2 or HeLa cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu SREBF2

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Andere Bezeichnung: SREBF2 (SREBF2 Produkte)

Synonyme: SREBF2 antikoerper, srebp2 antikoerper, SREBP2 antikoerper, zgc:158371 antikoerper, AI608257 antikoerper, SREBP-2 antikoerper, SREBP2gc antikoerper, bHLHd2 antikoerper, lop13 antikoerper, nuc antikoerper, Srebf2_retired antikoerper, sterol regulatory element binding transcription factor 2 antikoerper, sterol regulatory element binding factor 2 antikoerper, sterol regulatory element binding transcription factor 2 L homeolog antikoerper, SREBF2 antikoerper, srebf2 antikoerper, Srebf2 antikoerper, srebf2.L antikoerper

Hintergrund: AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding transcription factor 2,SREBP2
Cellular localisation: Nuclear and Cytoplasmic.

Molekulargewicht: 68/125kDa

Gen-ID: 6721, 443258

UniProt: Q12772

Pathways: Regulation of Lipid Metabolism by PPARalpha