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SERBP1 Antikörper (AA 3-139)

SERBP1 Reaktivität: Human WB, IHC, IHC (f) Wirt: Maus Monoclonal SERBP1-3491 unconjugated
Produktnummer ABIN6938368
  • Target Alle SERBP1 Antikörper anzeigen
    SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3-139
    Reaktivität
    • 46
    • 27
    • 12
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 31
    • 14
    Maus
    Klonalität
    • 34
    • 12
    Monoklonal
    Konjugat
    • 32
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SERBP1 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 13
    • 13
    • 13
    • 12
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-i± and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone’s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
    Kreuzreaktivität (Details)
    Human.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)
    Klon
    SERBP1-3491
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product SERBP1 Primärantikörper
  • Applikationshinweise

    Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
    Andere Bezeichnung
    SERBP1 (SERBP1 Produkte)
    Synonyme
    CHD3IP antikoerper, HABP4L antikoerper, PAI-RBP1 antikoerper, PAIRBP1 antikoerper, 1200009K13Rik antikoerper, 9330147J08Rik antikoerper, AL022786 antikoerper, Pairbp1 antikoerper, Pai-Rbp1 antikoerper, Rda288 antikoerper, cgi-55 antikoerper, chd3ip antikoerper, habp4l antikoerper, pai-rbp1 antikoerper, pairbp1 antikoerper, rda288 antikoerper, hm:zeh0245 antikoerper, serbp1 antikoerper, wu:fa12d05 antikoerper, wu:fb36e07 antikoerper, wu:fc16f12 antikoerper, wu:fj13e12 antikoerper, zgc:55489 antikoerper, SERPINE1 mRNA binding protein 1 antikoerper, serpine1 mRNA binding protein 1 antikoerper, Serpine1 mRNA binding protein 1 antikoerper, SERPINE1 mRNA binding protein 1 L homeolog antikoerper, SERPINE1 mRNA binding protein 1a antikoerper, SERBP1 antikoerper, Serbp1 antikoerper, serbp1.L antikoerper, serbp1a antikoerper
    Hintergrund
    CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1,SERBP1 / PAI-RBP1
    Cellular localisation: Cytoplasm and nucleus. Also found in perinuclear regions.
    Molekulargewicht
    60kDa
    Gen-ID
    26135, 530412
    UniProt
    Q8NC51
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