SERBP1 Antikörper (AA 3-139)

Produktnummer ABIN6939487

Der Maus Monoklonal anti-SERBP1 Antikörper wird verwendet zum Nachweis von SERBP1 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für SERBP1 Antikörper (AA 3-139) (ABIN6939487)

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SERBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: SERBP1-3493

Produktdetails anti-SERBP1 Antikörper

Bindungsspezifität: AA 3-139

Verwendungszweck: SERBP1 / PAI-RBP1 Antibody

Spezifität: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-°™ and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human kidney or bladder tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu SERBP1

Target: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Andere Bezeichnung: SERBP1

Hintergrund:

CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1

K562 or PC3 cells. Human kidney or bladder tissue (IHC).

Molekulargewicht: 60kDa

Gen-ID: 26135, 530412

UniProt: Q8NC51