RPSA/Laminin Receptor Antikörper

Produktnummer ABIN6938329

Dieses Anti-RPSA/Laminin Receptor-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von RPSA/Laminin Receptor in WB, IF, FACS und IHC (f). Geeignet für Human.

Kurzübersicht für RPSA/Laminin Receptor Antikörper (ABIN6938329)

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RPSA/Laminin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: RPSA-2699

Produktdetails anti-RPSA/Laminin Receptor Antikörper

Spezifität: Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-lengthhuman RPSA protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/mL), Immunofluorescence (1-2 μg/mL),Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: MCF-7, MDA-MB-453or HEK293 cells.Human breast, colon or ovarian carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu RPSA/Laminin Receptor

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Andere Bezeichnung: RPSA

Hintergrund: 34/67 kDa Laminin Receptor,37 kDa Laminin Receptor precursor,37/67 kDa Laminin Receptor, 37LRP,40S Ribosomal Protein SA,67 kDa Laminin Receptor, 67LR,Colon Carcinoma Laminin-binding Protein, LAMBR, Laminin receptor 1,Laminin-binding Protein precursor p40, LAMR1, LBP/p40, LRP/LR, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, Ribosomal Protein SA (RPSA),Laminin Receptor/ RPSA (Marker of Metastatic Potential)
Cellular localisation: Cell Surface,Cytoplasmic and Nuclear

Molekulargewicht: 37-67kDa

Gen-ID: 3921, 449909

UniProt: P08865

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly