Peroxiredoxin 4 Antikörper

Produktnummer ABIN6938231

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Peroxiredoxin 4 in ELISA und Coat. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Peroxiredoxin 4 Antikörper (ABIN6938231)

Target: Peroxiredoxin 4 (PRDX4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Peroxiredoxin 4 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Klon: CPTC-PRDX4-2

Produktdetails anti-Peroxiredoxin 4 Antikörper

Spezifität: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human PRDX4 protein

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Peroxiredoxin 4

Target: Peroxiredoxin 4 (PRDX4)

Andere Bezeichnung: PRDX4

Hintergrund: Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK,Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)
Cellular localisation: Cytoplasm. Secreted.

Molekulargewicht: 27kDa

Gen-ID: 10549, 83383

UniProt: Q13162