Rekombinanter POMC Antikörper (N-Term)
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- Target Alle POMC Antikörper anzeigen
- POMC (Proopiomelanocortin (POMC))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser POMC Antikörper ist unkonjugiert
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Applikation
- ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH), does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
- Kreuzreaktivität (Details)
- Human, Mouse and Rat. Expected to show a broad species reactivity.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- N-terminal fragment of human ACTH conjugated to KLH
- Klon
- R57
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product POMC Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (For coating, order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Normal pituitary gland or pituitary tumor.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- POMC (Proopiomelanocortin (POMC))
- Andere Bezeichnung
- POMC (POMC Produkte)
- Synonyme
- MSH antikoerper, ACTH antikoerper, pomc antikoerper, SI:bZ36D5.1 antikoerper, SI:bZ36D5.4 antikoerper, si:bz36d5.2 antikoerper, BE antikoerper, Beta-LPH antikoerper, Clip antikoerper, Gamma-LPH antikoerper, Npp antikoerper, Pomc-1 antikoerper, Pomc1 antikoerper, alpha-MSH antikoerper, alphaMSH antikoerper, beta-MSH antikoerper, gamma-MSH antikoerper, CLIP antikoerper, LPH antikoerper, NPP antikoerper, POC antikoerper, Pomc2 antikoerper, proopiomelanocortin a antikoerper, pro-opiomelanocortin-alpha antikoerper, proopiomelanocortin antikoerper, pomca antikoerper, Pomc antikoerper, POMC antikoerper
- Hintergrund
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Adrenocorticotropin, alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin, beta-Endorphin, beta or gamma Lipotropin (LPH), CLIP, Met Enkephalin, POC, POMC,ACTH (Adrenocorticotrophic Hormone) (N-Terminal) (Pituitary Marker)
Cellular localisation: Cytoplasm. Secreted. - Molekulargewicht
- ACTH is ~5kDa, and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
- Gen-ID
- 5443, 1897
- UniProt
- P01189
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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