Rekombinanter Nkx2-2 Antikörper (AA 1-119)

Produktnummer ABIN6938067

Der Kaninchen Monoklonal Anti-Nkx2-2-Antikörper wurde für IHC (f) validiert. Er ist geeignet, Nkx2-2 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter Nkx2-2 Antikörper (AA 1-119) (ABIN6938067)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Nkx2-2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: NX2-2198R

Produktdetails anti-Nkx2-2 Antikörper

Bindungsspezifität: AA 1-119

Spezifität: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human NKX2.2 protein fragment (around aa1-119) (exact sequence is proprietary)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.

Positive_Control: Pancreas or Ewing's sarcoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Andere Bezeichnung: NKX2-2

Hintergrund: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman,NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)
Cellular localisation: Nuclear

Molekulargewicht: 40-50kDa

Gen-ID: 4821, 516922

UniProt: O95096

Pathways: Dopaminergic Neurogenesis