Nkx2-2 Antikörper (AA 1-119)
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- Target Alle Nkx2-2 Antikörper anzeigen
- Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
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Bindungsspezifität
- AA 1-119
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Nkx2-2 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa1-119) of human NKX2.2 protein (exact sequence is proprietary)
- Klon
- NX2-1523
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product Nkx2-2 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
Positive_Control: Pancreas or Ewing's Sarcoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
- Andere Bezeichnung
- NKX2-2 (Nkx2-2 Produkte)
- Synonyme
- XeNK-2 antikoerper, Xnkx2.2 antikoerper, nkx2-2-A antikoerper, nkx2.2 antikoerper, NKX-2.2 antikoerper, NKX2.2 antikoerper, NKX2B antikoerper, Nkx-2.2 antikoerper, Nkx2.2 antikoerper, tinman antikoerper, id:ibd5090 antikoerper, nk2.2 antikoerper, nkx2-2 antikoerper, wu:fc83b01 antikoerper, zgc:136536 antikoerper, NK2 homeobox 2 S homeolog antikoerper, NK2 homeobox 2 antikoerper, NK2 homeobox 2a antikoerper, nkx2-2.S antikoerper, NKX2-2 antikoerper, Nkx2-2 antikoerper, nkx2.2a antikoerper
- Hintergrund
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Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman,NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)
Cellular localisation: Nuclear - Molekulargewicht
- 40-50kDa
- Gen-ID
- 4821, 516922
- UniProt
- O95096
- Pathways
- Dopaminergic Neurogenesis
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