NKX2-1 Antikörper
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- Target Alle NKX2-1 Antikörper anzeigen
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser NKX2-1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
- Kreuzreaktivität (Details)
- Human. Mouse. Rat. Shows a broad species reactivity.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Rat full length TTF-1 recombinant protein
- Klon
- 8G7G3-1
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product NKX2-1 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: MAD109, MLE-15, H441-4 or H345 cells. Normal thyroid or lung.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
- Andere Bezeichnung
- NKX2-1 (NKX2-1 Produkte)
- Synonyme
- BCH antikoerper, BHC antikoerper, NK-2 antikoerper, NKX2.1 antikoerper, NKX2A antikoerper, TEBP antikoerper, TITF1 antikoerper, TTF-1 antikoerper, TTF1 antikoerper, titf1-A antikoerper, Xnkx-2.1 antikoerper, NKX2-1 antikoerper, LOC100227803 antikoerper, AV026640 antikoerper, Nkx2.1 antikoerper, T/EBP antikoerper, Titf1 antikoerper, Ttf-1 antikoerper, nk2.1a antikoerper, nkx2.1 antikoerper, nkx2.4a antikoerper, titf1 antikoerper, titf1a antikoerper, NK2 homeobox 1 antikoerper, NK2 homeobox 1 L homeolog antikoerper, NK2 homeobox 4b antikoerper, NKX2-1 antikoerper, nkx2-1.L antikoerper, Nkx2-1 antikoerper, nkx2.4b antikoerper
- Hintergrund
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BCH, Benign chorea, BHC, Homeobox protein Nkx2.1, NK2 homeobox 1, NKX2.1, NKX2A, TEBP, Thyroid nuclear factor-1, Thyroid specific enhancer binding protein, Thyroid transcription factor-1 (TTF-1), Tin man, TITF1, TTF-1,TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker)
Cellular localisation: Nuclear - Molekulargewicht
- 40kDa
- Gen-ID
- 7080, 94367
- UniProt
- P43699
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
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