LSP1 Antikörper (AA 174-278)

Produktnummer ABIN6937790

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LSP1 in IHC (p) und IHC (f). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LSP1 Antikörper (AA 174-278) (ABIN6937790)

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LSP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: LSP1-3025

Produktdetails anti-LSP1 Antikörper

Bindungsspezifität: AA 174-278

Spezifität: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu LSP1

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Andere Bezeichnung: LSP1

Hintergrund: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1,Lymphocyte Specific Protein 1 (LSP1) / pp52
Cellular localisation: Membrane.

Molekulargewicht: 52kDa

Gen-ID: 4046, 56729

UniProt: P33241