Integrin beta 4 Antikörper

Produktnummer ABIN6937605

Der Maus Monoklonal Anti-Integrin beta 4-Antikörper wurde für FACS, IF, BR und Bind validiert. Er ist geeignet, Integrin beta 4 in Proben von Human zu detektieren.

Kurzübersicht für Integrin beta 4 Antikörper (ABIN6937605)

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Reagent (BR), Binding Studies (Bind)

Klon: UM-A9

Produktdetails anti-Integrin beta 4 Antikörper

Spezifität: Recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human squamous cell carcinoma (UM-SCC1)

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Biological Blockade (Partially blocks laminin binding) (Order Ab without Azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: A431 cells, squamous cell carcinoma, colon or placenta.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: ITGB4

Hintergrund: GP150, Integrin beta-4, ITGB4,CD104 (Integrin Beta-4) (Squamous Cell Carcinoma Antigen)
Cellular localisation: Cell Surface

Molekulargewicht: 205kDa

Gen-ID: 3691, 632226

UniProt: P16144

Pathways: Integrin Complex