CD51 Antikörper

Produktnummer ABIN6937590

Der Maus Monoklonal anti-CD51 Antikörper wird verwendet zum Nachweis von CD51 in Proben von Human und Huhn. Er wurde validiert für ELISA.

Kurzübersicht für CD51 Antikörper (ABIN6937590)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reaktivität: Human, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD51 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 23C6

Produktdetails anti-CD51 Antikörper

Verwendungszweck: Vitronectin Receptor / CD51 / CD61 Antibody

Spezifität: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

Keine Kreuzreaktivität: Rind (Kuh), Schwein, Kaninchen

Kreuzreaktivität (Details): Human. Chicken. Does not react with Bovine or Pig or Rabbit.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Osteoclasts from osteoclastomas

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: Squamous cells, A375M melanoma cells. A549 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Andere Bezeichnung: ITGAV

Hintergrund:

CD51, DKFZp686A08142, integrin alpha V beta 3, Integrin alpha-5 Integrin alpha-V light chain, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITGAV, Msk8, VNRA, VTNR

A375M melanoma cells. A549 cells., Squamous cells

Molekulargewicht: 150-160kDa under non-reducing conditions. Under reducing conditions|it is cleaved into 2 bands of about 125-130kDa +20-25kDa.

Gen-ID: 3685, 436873

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex