Frataxin Antikörper (AA 57-210)

Produktnummer ABIN6937289

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Frataxin in WB und IHC (f). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Frataxin Antikörper (AA 57-210) (ABIN6937289)

Target: Frataxin (FXN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Frataxin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: FXN-2124

Produktdetails anti-Frataxin Antikörper

Bindungsspezifität: AA 57-210

Spezifität: Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), a human autosomal recessive neurodegenerative disease. Lack of Frataxin causes iron to accumulate in the mitochondrial matrix suggesting that Frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport. Frataxin has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human Frataxin (FXN) protein (around aa 57-210) (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: HepG2, Panc-2, HL-60 or HEK293 cells. Pancreas and Liver.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Frataxin

Target: Frataxin (FXN)

Andere Bezeichnung: FXN

Hintergrund: CyaY, d-FXN, FARR, Frataxin mature form, Frataxin (81-210), FRDA, Friedreich ataxia protein, Fxn, i-FXN, m56-FXN, m78-FXN, m81-FXN, X25,Frataxin (Marker of Friedreich Ataxia)
Cellular localisation: Cytoplasmic (Mitochondria)

Molekulargewicht: 14kDa

Gen-ID: 2395, 20685

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size