Desmoglein 1 Antikörper (Intracellular)
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- Target Alle Desmoglein 1 (DSG1) Antikörper anzeigen
- Desmoglein 1 (DSG1)
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Bindungsspezifität
- Intracellular
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Desmoglein 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Spezifität
- Recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Human desmoglein-1 intracellular domain
- Klon
- 18D4
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product DSG1 Primärantikörper
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- Applikationshinweise
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL) Optimal dilution for a specific application should be determined.
Positive_Control: A431 or A-375 cells. Skin.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- Desmoglein 1 (DSG1)
- Andere Bezeichnung
- DSG1 (DSG1 Produkte)
- Synonyme
- CDHF4 antikoerper, DG1 antikoerper, DSG antikoerper, PPKS1 antikoerper, SPPK1 antikoerper, DSG-1 antikoerper, DSG1 antikoerper, Dsg1b antikoerper, Dsg1c antikoerper, desmoglein 1 antikoerper, desmoglein 4 antikoerper, DSG1 antikoerper, DSG4 antikoerper, Dsg1 antikoerper
- Hintergrund
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Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1,Desmoglein-1 (DSG1)
Cellular localisation: Cell surface - Molekulargewicht
- 150kDa (precursor), 160kDa (mature)
- Gen-ID
- 1828, 2633
- UniProt
- Q02413
- Pathways
- Cell-Cell Junction Organization
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