Cathepsin K Antikörper (AA 163-274)

Produktnummer ABIN6937059

Der Maus Monoklonal Anti-Cathepsin K-Antikörper wurde für IHC und IHC (f) validiert. Er ist geeignet, Cathepsin K in Proben von Human zu detektieren.

Kurzübersicht für Cathepsin K Antikörper (AA 163-274) (ABIN6937059)

Target: Cathepsin K (CTSK)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin K Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: CTSK-2791

Produktdetails anti-Cathepsin K Antikörper

Bindungsspezifität: AA 163-274

Spezifität: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human liver or breast tissue (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Cathepsin K

Target: Cathepsin K (CTSK)

Andere Bezeichnung: CTSK

Hintergrund: Cathepsin K, Cathepsin O, Cathepsin O1, Cathepsin O2, Cathepsin X, CTS02, Ctsk, CTSO1, CTSO2, PKND, PYCD,Cathepsin K (Marker of Tumor Invasiveness)
Cellular localisation: Cytoplasmic

Molekulargewicht: 39kDa

Gen-ID: 1513, 632466

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades