Cathepsin D Antikörper (AA 104-250)

Produktnummer ABIN6937054

Produktdetails anti-Cathepsin D Antikörper

Target: Cathepsin D (CTSD)

Bindungsspezifität: AA 104-250

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Spezifität: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Klon: CTSD-2781

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K-562, MCF-7 or SK-BR3 cells. Human kidney, liver, lung or breast tissues.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu Cathepsin D

Target: Cathepsin D (CTSD)

Andere Bezeichnung: CTSD (CTSD Produkte)

Synonyme: catD antikoerper, fb93e11 antikoerper, fj17b09 antikoerper, wu:fb93e11 antikoerper, wu:fj17b09 antikoerper, LOC398557 antikoerper, Cathd antikoerper, CatD antikoerper, LOC100136761 antikoerper, CTSD antikoerper, DKFZp469J0315 antikoerper, DDBDRAFT_0205785 antikoerper, DDBDRAFT_0215012 antikoerper, DDB_0205785 antikoerper, DDB_0215012 antikoerper, CLN10 antikoerper, CPSD antikoerper, CD antikoerper, cathepsin D antikoerper, cathepsin D S homeolog antikoerper, lysosomal aspartic protease antikoerper, cathepsin D-like antikoerper, ctsd antikoerper, LOC398557 antikoerper, ctsd.S antikoerper, CatD antikoerper, LOC5567565 antikoerper, LOC100136761 antikoerper, CTSD antikoerper, Cathd antikoerper, ctsD antikoerper, catd antikoerper, Ctsd antikoerper, LOC443060 antikoerper

Hintergrund: CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease,Cathepsin D (Tumor Marker)
Cellular localisation: Cytoplasmic

Molekulargewicht: 48kDa (Procathepsin D), 34kDa (Cathepsin D), 14kDa (Cathepsin D)

Gen-ID: 1509, 654447

UniProt: P07339

Pathways: Peptide Hormone Metabolism