CPS1 Antikörper
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- Target Alle CPS1 Antikörper anzeigen
- CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CPS1 Antikörper ist unkonjugiert
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Applikation
- Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC's occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
- Kreuzreaktivität (Details)
- Human. Dog.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human CPS1 protein
- Klon
- SPM615
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CPS1 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1 mM EDTA, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Liver or Hepatocellular Carcinoma (HCC).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
- Andere Bezeichnung
- CPS1 (CPS1 Produkte)
- Synonyme
- CPSASE1 antikoerper, cps antikoerper, 4732433M03Rik antikoerper, CPS antikoerper, D1Ucla3 antikoerper, Cps1 antikoerper, carbamoyl-phosphate synthase 1 antikoerper, carbamoyl-phosphate synthase 1 L homeolog antikoerper, carbamoyl-phosphate synthetase 1 antikoerper, peptidase M20 domain containing 1 antikoerper, CPS1 antikoerper, Cps1 antikoerper, cps1.L antikoerper, cps1 antikoerper, PM20D1 antikoerper
- Hintergrund
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Carbamoyl-phosphate synthetase 1 (CPS1), Carbamoylphosphate synthetase 1, CPSase 1, CPSASE1,CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker)
Cellular localisation: Finely granular cytoplasmic - Molekulargewicht
- ~165kDa
- Gen-ID
- 1373, 149252
- UniProt
- P31327
- Pathways
- Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
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