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CPS1 Antikörper

CPS1 Reaktivität: Human, Hund IF, IHC, StM Wirt: Maus Monoclonal SPM615 unconjugated
Produktnummer ABIN6939176
  • Target Alle CPS1 Antikörper anzeigen
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Reaktivität
    • 54
    • 29
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Hund
    Wirt
    • 63
    • 6
    Maus
    Klonalität
    • 52
    • 17
    Monoklonal
    Konjugat
    • 28
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CPS1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 24
    • 14
    • 14
    • 12
    • 10
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC's occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human CPS1 protein
    Klon
    SPM615
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CPS1 Primärantikörper
  • Applikationshinweise

    Positive Control: HeLa cells. Liver or Hepatocellular Carcinoma (HCC).

    Known Application: Immunofluorescence (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 1 mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Andere Bezeichnung
    CPS1 (CPS1 Produkte)
    Synonyme
    CPSASE1 antikoerper, cps antikoerper, 4732433M03Rik antikoerper, CPS antikoerper, D1Ucla3 antikoerper, Cps1 antikoerper, carbamoyl-phosphate synthase 1 antikoerper, carbamoyl-phosphate synthase 1 L homeolog antikoerper, carbamoyl-phosphate synthetase 1 antikoerper, peptidase M20 domain containing 1 antikoerper, CPS1 antikoerper, Cps1 antikoerper, cps1.L antikoerper, cps1 antikoerper, PM20D1 antikoerper
    Molekulargewicht
    ~165kDa
    Gen-ID
    1373
    UniProt
    P31327
    Pathways
    Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
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