Rekombinanter Transferrin Receptor Antikörper (AA 94-212)

Produktnummer ABIN6936803

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Transferrin Receptor in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Transferrin Receptor Antikörper (AA 94-212) (ABIN6936803)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TFRC-2898R

Produktdetails anti-Transferrin Receptor Antikörper

Bindungsspezifität: AA 94-212

Verwendungszweck: Recombinant CD71 / Transferrin Receptor (TFRC) (Extracellular Domain) Antibody

Spezifität: It recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human extracellular TFRC protein fragment (aa94-212) (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: CD71 / Transferrin Receptor (TFRC)

Hintergrund:

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

HeLa, Jurkat, MCF-7 or K562 cells. Human placenta or Bone Marrow.

Molekulargewicht: 85-95kDa (monomer), 190kDa (dimer)

Gen-ID: 7037, 529618

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis