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Aurora Kinase B Antikörper (AA 89-251)

AURKB Reaktivität: Human WB Wirt: Maus Monoclonal AURKB-1521 unconjugated

Produktnummer ABIN6936440

Datenblatt (PDF)

Target Alle Aurora Kinase B (AURKB) Antikörper anzeigen

Aurora Kinase B (AURKB)
Bindungsspezifität
19

19

13

11

10

8

8

7

6

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 89-251
Reaktivität
117

66

34

14

4

4

2

1

1

1

1

1
Human
Wirt
113

23

3

1
Maus
Passende Sekundärantikörper
Klonalität
101

40
Monoklonal
Konjugat
80

10

7

6

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser Aurora Kinase B Antikörper ist unkonjugiert
Applikation
84

59

43

35

16

14

14

13

8

6

4

3

3

3

2

2

2

1

1
Western Blotting (WB)

Spezifität

Recognizes a protein of 39 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Kreuzreaktivität (Details)

Human.

Aufreinigung

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen

Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)

Klon

AURKB-1521

Isotyp

IgG1 kappa

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anti-Aurora Kinase B (AURKB) (AA 89-251) antibody
AURKB Reaktivität: Human IHC, StM Wirt: Maus Monoclonal rAURKB-1592 unconjugated Recombinant Antibody

anti-Aurora Kinase B (AURKB) (pThr232) antibody
AURKB Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) (AA 1-255) antibody
AURKB Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) (AA 89-251) antibody
AURKB Reaktivität: Human IHC, StM Wirt: Maus Monoclonal AURKB-1592 unconjugated

anti-Aurora Kinase B (AURKB) (pThr232) antibody
AURKB Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Known_Application: Western Blot (1-2ug/ml); Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells. Tonsil, Placenta, Hodgkin's Lymphoma or Colon Carcinoma.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1.0 mg/mL

Buffer

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel

Azide free

Lagerung

-20 °C,-80 °C

Informationen zur Lagerung

Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit

24 months
Target

Aurora Kinase B (AURKB)

Andere Bezeichnung

AURKB (AURKB Produkte)

Hintergrund

AIK2, AIM-1, ARK-2, AurB, AURKB, Aurora-1, Aurora and Ipl1 like midbody associated protein 1, Aurora kinase B, Aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, IPL1, Protein phosphatase 1 regulatory subunit 48 (PPP1R48), Serine/threonine-protein kinase 12, Serine/threonine-protein kinase aurora-B, STK1, STK12, STK5,Aurora B (Proliferation Marker)
Cellular localisation: Nuclear and Cytoplasmic

Molekulargewicht

39kDa

Gen-ID

9212, 442658

UniProt

Q96GD4

Pathways

T-Zell Rezeptor Signalweg, Zellzyklus, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades