APCS Antikörper (AA 143-223)

Produktnummer ABIN6936424

Dieses Anti-APCS-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von APCS in IHC und IHC (f). Geeignet für Human.

Kurzübersicht für APCS Antikörper (AA 143-223) (ABIN6936424)

Target: APCS (Amyloid P Component, Serum (APCS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APCS Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: APCS-3240

Produktdetails anti-APCS Antikörper

Bindungsspezifität: AA 143-223

Spezifität: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human endometrial carcinoma tissue (IHC).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Andere Bezeichnung: APCS

Hintergrund: 9.5S alpha 1 glycoprotein, Amyloid P component serum (APCS), Pentaxin related, Pentraxin 2 (PTX2), Serum Amyloid P (SAP), Serum amyloid P component,Serum Amyloid P / APCS
Cellular localisation: Secreted.

Molekulargewicht: 200kDa (oligomeric), 26kDa (non-covalently bound subunit), 30kDa (glycosylated SAP subunit)

Gen-ID: 325, 507080

UniProt: P02743