ACP5 Antikörper
-
- Target Alle ACP5 Antikörper anzeigen
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
-
Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser ACP5 Antikörper ist unkonjugiert
-
Applikation
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
- Kreuzreaktivität (Details)
- Human. Mouse. Rat.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human ACP5 protein
- Klon
- ACP5-1070
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product ACP5 Primärantikörper
-
-
- Applikationshinweise
-
Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HepG2, 293T, K562 or RPMI-8226 cells. Spleen from Hairy Cell Leukemia (HCL) patient.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
-
- Target
- ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
- Andere Bezeichnung
- ACP5 (ACP5 Produkte)
- Synonyme
- SPENCDI antikoerper, TRAP antikoerper, acp5 antikoerper, sb:cb576 antikoerper, zgc:63825 antikoerper, wu:fb19f01 antikoerper, wu:fb30b03 antikoerper, wu:fi14e01 antikoerper, wu:fj66f03 antikoerper, MGC78938 antikoerper, MGC89674 antikoerper, TR-AP antikoerper, zgc:92339 antikoerper, TRACP antikoerper, TTRRAP antikoerper, Trap antikoerper, UF antikoerper, acid phosphatase 5, tartrate resistant antikoerper, acid phosphatase 5a, tartrate resistant antikoerper, acid phosphatase 5, tartrate resistant S homeolog antikoerper, tartrate resistant acid phosphatase antikoerper, Tartrate-resistant acid phosphatase type 5 antikoerper, tartrate-resistant acid phosphatase type 5 antikoerper, acid phosphatase 5b, tartrate resistant antikoerper, ACP5 antikoerper, acp5a antikoerper, acp5.S antikoerper, acp5 antikoerper, NAEGRDRAFT_81291 antikoerper, ppa5 antikoerper, LOC100282899 antikoerper, acp5b antikoerper, Acp5 antikoerper
- Hintergrund
-
Acid phosphatase 5, tartrate resistant, ACP5, serum band 5 tartrate-resistant acid phosphatase, SPENCDI, Tartrate-resistant acid ATPase, Tartrate-resistant acid phosphatase type 5, TR-AP, TRACP5, TRAcP, TRAP, TrATPase, Type 5 acid phosphatase,TRAcP (Tartrate-Resistant Acid Phosphatase) (Hairy Cell Leukemia Marker)
Cellular localisation: Cytoplasmic (Lysosomes) - Molekulargewicht
- 35kDa
- Gen-ID
- 54, 1211
- UniProt
- P13686
- Pathways
- Transition Metal Ion Homeostasis
-