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Rekombinanter ACP5 Antikörper

ACP5 Reaktivität: Human, Maus, Ratte IHC, StM Wirt: Kaninchen Monoclonal ACP5-2336R unconjugated Recombinant Antibody
Produktnummer ABIN6940367
  • Target Alle ACP5 Antikörper anzeigen
    ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 77
    • 41
    • 27
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 59
    • 23
    • 2
    • 2
    Kaninchen
    Klonalität
    • 63
    • 23
    Monoklonal
    Konjugat
    • 49
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ACP5 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 28
    • 21
    • 19
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    It recognizes a protein of 35 kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human ACP5 protein
    Klon
    ACP5-2336R
    Isotyp
    IgG
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  • Applikationshinweise

    Positive Control: HepG2, 293T, K562 or RPMI-8226 cells. Spleen from Hairy Cell Leukemia (HCL) patient.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    ACP5 (Acid Phosphatase 5, Tartrate Resistant (ACP5))
    Andere Bezeichnung
    ACP5 (ACP5 Produkte)
    Synonyme
    SPENCDI antikoerper, TRAP antikoerper, acp5 antikoerper, sb:cb576 antikoerper, zgc:63825 antikoerper, wu:fb19f01 antikoerper, wu:fb30b03 antikoerper, wu:fi14e01 antikoerper, wu:fj66f03 antikoerper, MGC78938 antikoerper, MGC89674 antikoerper, TR-AP antikoerper, zgc:92339 antikoerper, TRACP antikoerper, TTRRAP antikoerper, Trap antikoerper, UF antikoerper, acid phosphatase 5, tartrate resistant antikoerper, acid phosphatase 5a, tartrate resistant antikoerper, acid phosphatase 5, tartrate resistant S homeolog antikoerper, tartrate resistant acid phosphatase antikoerper, Tartrate-resistant acid phosphatase type 5 antikoerper, tartrate-resistant acid phosphatase type 5 antikoerper, acid phosphatase 5b, tartrate resistant antikoerper, ACP5 antikoerper, acp5a antikoerper, acp5.S antikoerper, acp5 antikoerper, NAEGRDRAFT_81291 antikoerper, ppa5 antikoerper, LOC100282899 antikoerper, acp5b antikoerper, Acp5 antikoerper
    Molekulargewicht
    35kDa
    Gen-ID
    54
    UniProt
    P13686
    Pathways
    Transition Metal Ion Homeostasis
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