Chromogranin A Antikörper (CF®488A)

Produktnummer ABIN6934169

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Chromogranin A in IF, FACS und T. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Chromogranin A Antikörper (CF®488A) (ABIN6934169)

Target: Chromogranin A (CHGA)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Chromogranin A Antikörper ist konjugiert mit CF®488A

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Test (T)

Klon: CGA-414

Produktdetails anti-Chromogranin A Antikörper (CF®488A)

Spezifität: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Kreuzreaktivität (Details): Human,

Aufreinigung: Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules.

Immunogen: Recombinant human chromogranin A protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Positive Control: PC12 cells. Adrenal gland, bowel, thyroid, pancreas or pheochromocytoma.

Known Application: Flow Cytometry (5 µL per test per one million cells or 5 µL per 100 µL of whole blood),Immunofluorescence (1:50-1:100),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Haltbarkeit: 24 months

Details zu Chromogranin A

Target: Chromogranin A (CHGA)

Andere Bezeichnung: CHGA

Hintergrund: Beta-Granin, CGA, CHGA, Chromogranin A Parathyroid Secretory Protein 1, ER-37, Pancreastatin, Parastatin, Parathyroid Secretory Protein 1, Pituitary Secretory Protein I, SP-I, Vasostatin I or II,Chromogranin A / CHGA (Neuroendocrine Marker)
Cellular localisation: Finely granular cytoplasmic

Molekulargewicht: 68-75kDa

Gen-ID: 1113, 150793

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling