FOXO3 Antikörper (pSer253) (Biotin)
Kurzübersicht für FOXO3 Antikörper (pSer253) (Biotin) (ABIN684720)
Target
Alle FOXO3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- pSer253
-
Spezifität
- This phosphorylation site is homologous to Ser252 in Mouse and Rat.
-
Kreuzreaktivität
- Human, Maus, Ratte
-
Homologie
- Dog,Cow,Sheep,Pig,Horse,Chicken
-
Aufreinigung
- Purified by Protein A.
-
Immunogen
- KLH conjugated synthetic phosphopeptide derived from human FoxO3a around the phosphorylation site of Ser253
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 μg/μL
-
Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
Konservierungsmittel
- ProClin
-
Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20°C for 12 months.
-
Haltbarkeit
- 12 months
-
-
- FOXO3 (Forkhead Box O3 (FOXO3))
-
Andere Bezeichnung
- Foxo3a
-
Hintergrund
-
Synonyms: FOXO2, AF6q21, FKHRL1, FOXO3A, FKHRL1P2, Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FOXO3
Background: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34C expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
-
Gen-ID
- 2309
-
UniProt
- O43524
-
Pathways
- Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis
Target
-