HDAC6 Antikörper (AA 301-400)

Produktnummer ABIN681058

Produktdetails anti-HDAC6 Antikörper

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Bindungsspezifität: AA 301-400

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HDAC6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Andere Bezeichnung: HDAC6 (HDAC6 Produkte)

Synonyme: HD6 antikoerper, Hd6 antikoerper, Hdac5 antikoerper, Sfc6 antikoerper, mHDA2 antikoerper, CG6170 antikoerper, DHDAC2 antikoerper, DmHDAC2 antikoerper, Dmel\\CG6170 antikoerper, HDAC antikoerper, HDAC2 antikoerper, dHDAC2 antikoerper, dHDAC6 antikoerper, dmHDA404 antikoerper, hdac6 antikoerper, MGC53140 antikoerper, wu:fc31d02 antikoerper, dsim_GLEANR_17355 antikoerper, DsimGD17207 antikoerper, GD17207 antikoerper, HDAC6 antikoerper, ATHDA6 antikoerper, AXE1 antikoerper, HISTONE DEACETYLASE 6 antikoerper, MDC12.7 antikoerper, MDC12_7 antikoerper, RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1 antikoerper, RPD3B antikoerper, RTS1 antikoerper, SIL1 antikoerper, histone deacetylase 6 antikoerper, histone deacetylase 6 antikoerper, Histone deacetylase 6 antikoerper, histone deacetylase 6 L homeolog antikoerper, GD17207 gene product from transcript GD17207-RB antikoerper, Histone DeAcetylase antikoerper, HDAC6 antikoerper, Hdac6 antikoerper, hdac6.L antikoerper, hdac6 antikoerper, Dsim\HDAC6 antikoerper, PTRG_03035 antikoerper, HDA6 antikoerper, hda-6 antikoerper

Hintergrund:

Synonyms: HD6, JM21, CPBHM, PPP1R90, Histone deacetylase 6, HDAC6, KIAA0901

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Gen-ID: 10013

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling