CCL2 Antikörper

Produktnummer ABIN675863

Der Kaninchen Polyklonal Anti-CCL2-Antikörper wurde für WB, IHC (p) und IF (p) validiert. Er ist geeignet, CCL2 in Proben von Human, Maus, Ratte, Hund, Schwein und Rind (Kuh) zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für CCL2 Antikörper (ABIN675863)

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-CCL2 Antikörper

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Referenzen für anti-CCL2 Antikörper (ABIN675863)

Heilmann, Schinke, Bindl, Wehner, Rapp, Haffner-Luntzer, Nemitz, Liedert, Amling, Ignatius: "The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing." in: PLoS ONE, Vol. 8, Issue 12, pp. e84232, (2014) (PubMed).

Su, Min, Cao, Yan, Zhao, Li, Chai, Mei, Yang, Zhang, Zhang, Liu, Sun, Che, Yang: "LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria." in: Nature communications, Vol. 5, pp. 4434, (2014) (PubMed).

Kong, Luo, Li, Zhou, He: "The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits." in: Lipids in health and disease, Vol. 12, pp. 115, (2013) (PubMed).

Details zu CCL2

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Andere Bezeichnung: MCP1/CCL2

Hintergrund:

Synonyms: C-C motif chemokine 2, HC11, Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, MCAF, Monocyte chemotactic protein 1, MCP-1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2, CCL-2, MCP1, SCYA2

Background: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Molekulargewicht: 11kDa

Gen-ID: 6347

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion