BCL2L1 Antikörper (pSer62)

Produktnummer ABIN675144

Dieses Anti-BCL2L1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BCL2L1 in WB, IHC (p) und IF (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für BCL2L1 Antikörper (pSer62) (ABIN675144)

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-BCL2L1 Antikörper

Bindungsspezifität: pSer62

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Bcl-xL around the phosphorylation site of Ser62

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:100-1000, IHC-P: 1:100-500, IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: Bcl-Xl/Bcl2l1

Hintergrund:

Synonyms: BCL2L1 phospho S62, p-BCL2L1 phospho S62,Apoptosis regulator Bcl X, BclX, Bcl-X, Bcl 2 like 1, Bcl 2 like 1 protein, Bcl xL, BCL X/L, BCL XL/S, Bcl xS, Bcl2 like1, BCL2-related gene, BCL2-related protein, long isoform, included, BCLXL, included, BCL2-related protein, short isoform, included, BCLXS, included, BCL2L, BCL2L1, Bclx, DKFZp781P2092, MGC113803, MGC99998, B2CL1_HUMAN.

Background: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Gen-ID: 598

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling