PTCRA Antikörper (AA 24-143)

Produktnummer ABIN6719646

Dieses Anti-PTCRA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PTCRA in WB und ELISA. Geeignet für Human.

Kurzübersicht für PTCRA Antikörper (AA 24-143) (ABIN6719646)

Target: PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTCRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PTCRA Antikörper

Bindungsspezifität: AA 24-143

Verwendungszweck: Anti-PTCRA Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PTCRA Antibody Picoband® (ABIN6719646). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human PTCRA recombinant protein (Position: T24-T143).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Aifantis, I., Borowski, C., Gounari, F., Lacorazza, H. D., Nikolich-Zugich, J., von Boehmer, H. A critical role for the cytoplasmic tail of pT-alpha in T lymphocyte development. Nature Immun. 3: 483-488, 2002. Note: Erratum: Nature Immun. 3: 591 only, 2002. 2. Del Porto, P., Bruno, L., Mattei, M.-G., von Boehmer, H., Saint-Ruf, C. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. Proc. Nat. Acad. Sci. 92: 12105-12109, 1995. 3. Saint-Ruf, C., Lechner, O., Feinberg, J., von Boehmer, H. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. Europ. J. Immun. 28: 3824-3831, 1998.

Kommentare:

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu PTCRA

Target: PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))

Andere Bezeichnung: PTCRA

Hintergrund:

Synonyms: Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR, PTCRA

Tissue Specificity: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Background: This PTCRA gene is mapped to 6p21.1. The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 29 kDa

Gen-ID: 171558

Pathways: Cancer Immune Checkpoints