KIF15 Antikörper (AA 1201-1388)

Produktnummer ABIN6719385

Produktdetails anti-KIF15 Antikörper

Target: KIF15 (Kinesin Family Member 15 (KIF15))

Bindungsspezifität: AA 1201-1388

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF15 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for KIF15 detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for KIF15 detection. Tested with WB, IHC-P, Direct ELISA in Human,Mouse,Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human KIF15 recombinant protein (Position: M1201-S1388).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application details: Western blot|0.1-0.5 μg/mL Immunohistochemistry(Paraffin-embedded Section)|0.5-1 μg/mL Direct ELISA|0.1-0.5 μg/mL

Kommentare:

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu KIF15

Target: KIF15 (Kinesin Family Member 15 (KIF15))

Andere Bezeichnung: KIF15 (KIF15 Produkte)

Synonyme: XKlp2 antikoerper, kif15 antikoerper, klp2 antikoerper, KIF15 antikoerper, si:dkey-108k21.1 antikoerper, wu:fb96c12 antikoerper, wu:fc51g12 antikoerper, wu:fe01e02 antikoerper, HKLP2 antikoerper, KNSL7 antikoerper, NY-BR-62 antikoerper, 3110023M17Rik antikoerper, 3930402I10Rik antikoerper, D330038N01 antikoerper, Knsl7 antikoerper, b2b1117.1Clo antikoerper, kinesin family member 15 L homeolog antikoerper, kinesin family member 15 antikoerper, kinesin family member 15 S homeolog antikoerper, zinc finger protein 660 antikoerper, kif15.L antikoerper, KIF15 antikoerper, kif15.S antikoerper, kif15 antikoerper, Kif15 antikoerper, ZNF660 antikoerper

Hintergrund:

Synonyms: Kinesin-like protein KIF15, Kinesin-like protein 2, hKLP2, Kinesin-like protein 7, Serologically defined breast cancer antigen NY-BR-62, KIF15, KLP2, KNSL7

Background: Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene. It is mapped to 3p21.31. This gene encodes a motor protein that is part of the kinesin superfamily. KIF15 maintains half spindle separation by opposing forces generated by other motor proteins. KIF15 co-localizes with microtubules and actin filaments in both dividing cells and in postmitotic neurons. KIF15 (also known as Kinesin-12 and HKLP2) is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth. KIF15 maintains bipolar microtubule spindle apparatus in dividing cells and shares redundant functions with KIF11. KIF15 is thought to promote spindle assembly by cross-linking and sliding along microtubules creating a separation between centrosomes. HeLa cells depleted of KIF11, with reduced microtubule dynamics, are able to form bipolar spindles from acentrosomal asters in a KIF15 dependent manner. Hence, inhibition of KIF15 function will be a vital therapeutic approach in cancer chemotherapy.

Gen-ID: 56992