COL3 Antikörper (AA 1301-1400)

Produktnummer ABIN669981

Produktdetails anti-COL3 Antikörper

Target: COL3 (Collagen, Type III (COL3))

Bindungsspezifität: AA 1301-1400

Reaktivität: Human, Ratte, Maus, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody is produced with an immunogen contained within the COLFI propeptide region, it will only recognize the full length Collagen III protein and not the mature form.

Kreuzreaktivität: Hund, Human, Maus, Kaninchen, Ratte

Homologie: Cow,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Collagen alpha 1(III) chain (C-terminal propeptide)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-COL3 Antikörper (ABIN669981)

Velázquez, Enos, Carson, Cranford, Bader, Sougiannis, Pritchett, Fan, Carson, Murphy: "miR155 deficiency aggravates high-fat diet-induced adipose tissue fibrosis in male mice." in: Physiological reports, Vol. 5, Issue 18, (2018) (PubMed).

Bai, Wu, Hong, Zhang, Liu, Chen: "Anti‑fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 737-745, (2017) (PubMed).

Yu, Liu, Sun, Wang, Wang, Zhao, Dai, Zhao, Zhang, Li, Han, Lu, Dong, Liu, Yu, Li: "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." in: Oncotarget, Vol. 8, Issue 23, pp. 37705-37716, (2017) (PubMed).

Yang, Zhao, Wang, Liu, Ma, Huang, Liu: "Isolation and biological characterization of tendon-derived stem cells from fetal bovine." in: In vitro cellular & developmental biology. Animal, Vol. 52, Issue 8, pp. 846-56, (2017) (PubMed).

Zhu, Hu, Yu, Ren, Hu: "High Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 3438-3445, (2016) (PubMed).

Jiang, Chun, Wang, Du, Wang, Xiong: "Effect of transforming growth factor-β3 on the expression of Smad3 and Smad7 in tenocytes." in: Molecular medicine reports, Vol. 13, Issue 4, pp. 3567-73, (2016) (PubMed).

Bai, Lu, Lin, Xu, Hu, Liang, Hong, Chen: "Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis." in: International journal of molecular medicine, Vol. 37, Issue 5, pp. 1317-27, (2016) (PubMed).

Su, Zhao, Shi, Zhang, Yu, Xie, Guo, Zhang, Liu, Shen, Wang, Li, Zhang, Zhou: "Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7." in: Molecular cancer, Vol. 13, pp. 206, (2016) (PubMed).

Wang, Li, Huang, Wang: "The influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring." in: BioMed research international, Vol. 2014, pp. 419805, (2015) (PubMed).

Zhao, Zhang, Chen, Gu, Ni, Shao, Wu, Qin: "Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation." in: BMC cardiovascular disorders, Vol. 14, pp. 167, (2015) (PubMed).

Details zu COL3

Target: COL3 (Collagen, Type III (COL3))

Andere Bezeichnung: Collagen 3 (COL3 Produkte)

Synonyme: PT antikoerper, RPRGL2 antikoerper, THPH1 antikoerper, Cf-2 antikoerper, Cf2 antikoerper, FII antikoerper, thrombin antikoerper, prothrombin antikoerper, coagulation factor II, thrombin antikoerper, coagulation factor II antikoerper, F2 antikoerper

Hintergrund:

Synonyms: EDS4A, Collagen alpha-1(III) chain, COL3A1

Background: Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.

Gen-ID: 1281

UniProt: P02461