MERTK Antikörper (AA 501-600) (HRP)
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- Target Alle MERTK Antikörper anzeigen
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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Bindungsspezifität
- AA 501-600
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MERTK Antikörper ist konjugiert mit HRP
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human of human MERTK
- Isotyp
- IgG
- Top Product
- Discover our top product MERTK Primärantikörper
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- Applikationshinweise
- IHC-P 1:200-400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
- Andere Bezeichnung
- MERTK (MERTK Produkte)
- Synonyme
- MER antikoerper, RP38 antikoerper, c-mer antikoerper, Eyk antikoerper, Mer antikoerper, Nyk antikoerper, nmf12 antikoerper, rdy antikoerper, C-EYK antikoerper, MERTK antikoerper, DKFZp469D2215 antikoerper, si:ch1073-268l12.2 antikoerper, MER proto-oncogene, tyrosine kinase antikoerper, c-mer proto-oncogene tyrosine kinase antikoerper, c-mer proto-oncogene tyrosine kinase a antikoerper, MERTK antikoerper, Mertk antikoerper, mertka antikoerper
- Hintergrund
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Synonyms: MER, RP38, c-Eyk, c-mer, Tyro12, Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
- Gen-ID
- 10461
- UniProt
- Q12866
- Pathways
- RTK Signalweg
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