ADRB1 Antikörper (AA 181-250)

Produktnummer ABIN669351

Dieses Anti-ADRB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ADRB1 in WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p) und IHC (fro). Geeignet für Human, Ratte und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für ADRB1 Antikörper (AA 181-250) (ABIN669351)

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ADRB1 Antikörper

Bindungsspezifität: AA 181-250

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADRB1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ADRB1 Antikörper (ABIN669351)

Bornholz, Benninghaus, Reinke, Felix, Roggenbuck, Jahns-Boivin, Jahns, Boege: "A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of ?1-adrenergic receptor autoantibodies in human heart disease." in: Clinical chemistry and laboratory medicine : CCLM / FESCC, (2015) (PubMed).

Deng, Liu, Zhang, Wang, Peng, Wei, Jiang: "Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model." in: Journal of experimental & clinical cancer research : CR, Vol. 33, pp. 21, (2014) (PubMed).

Details zu ADRB1

Target: ADRB1 (Adrenergic, beta-1-, Receptor (ADRB1))

Andere Bezeichnung: ADRB1

Hintergrund:

Synonyms: RHR, B1AR, ADRB1R, BETA1AR, Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor, ADRB1

Background: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

Gen-ID: 153

UniProt: P08588

Pathways: cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Brown Fat Cell Differentiation